Dysfunctional Neural Plasticity in Patients With Schizophrenia
نویسندگان
چکیده
منابع مشابه
Dysfunctional neural plasticity in patients with schizophrenia.
CONTEXT Neural plasticity in the human cortex involves a reorganization of synaptic connections in an effort to adapt to a changing environment. In schizophrenia, dysfunctional neural plasticity has been proposed as a key pathophysiological mechanism. OBJECTIVE To evaluate neural plasticity in unmedicated and medicated patients with schizophrenia compared with healthy subjects. DESIGN Neura...
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No current biological hypothesis can assimilate the genetic, environmental, and clinical features of schizophrenia. If, as some authors contend, environmental factors have important effects on the course of schizophrenia, then a fruitful research concern may be the adaptation of neuronal circuitry to environmental changes. The plasticity of neuronal connections has been studied by subjecting an...
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Thalamus abnormalities are common in neurological and psychiatric illnesses. Therefore, it is essential to understand the properties of the thalamus-related networks. The thalamic reticular nucleus (TRN) is a thin GABAergic layer interface strategically located between the thalamus and the neocortex. It is, at the very beginning of life, an essential neurodevelopmental guide for the accurate bu...
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ژورنال
عنوان ژورنال: Archives of General Psychiatry
سال: 2008
ISSN: 0003-990X
DOI: 10.1001/archpsyc.65.4.378